Studi scientifici

endoplus

Gli studi scientifici

Endoplus è il frutto della ricerca portata avanti durante gli ultimi 20 anni dal team scientifico della Fondazione Italiana Endometriosi. Grazie all’esperienza medica e al rapporto diretto con i pazienti la Fondazione costituisce oggi una delle realtà maggiormente competenti e coinvolte nella ricerca scientifica sull’endometriosi.

Endoplus è riconosciuto come uno dei migliori ausili per contrastare i sintomi infiammatori ossia la causa determinante l’endometriosi.

Consulta gli studi pubblicati sulle testate scientifiche internazionali:

 Journal of Cellular Physiology

“Novel dietary supplemente association reduces symptoms in endometriosi patiens”
Pieto G. Signorile | Rosa Viceconte | Alfonso Baldi

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6 componenti scelti dalla ricerca scientifica, ognuno per le sue proprietà specifiche.

Consulta gli approfondimenti scientifici relativi a tutti i nutrienti di Endoplus:

1. I benefici del Partenio

“Novel dietary supplemente association reduces symptoms in endometriosi patiens”
Pietro G. Signorile | Rosa Viceconte | Alfonso Baldi

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2. I benefici della Quercetina

“Treatment approaches for painful bladder syndrome/interstitial cystis”
Drugs – 2007
Theoharides TC

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“Inhibition effect and mechanism of quercetin on surgically induced endometriosis”
Sichuan da xue xue bao yi xue ban -2009 mar
Zhang X. | Wang X. | Wng HJ. | Jang Q. | Qie MR.

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“Preliminary study of Quercetin affecting the hypotalamic-pituitary-godanal axis on rat endometriosis model”
Evid based complement alternat med – 2014
Cao Y. | Zhuang MF. | Yang Y. | Xie SW. | Cui JG. | Cao L. | Zhu Y.

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“Quercetin alleviates generalized hyperalgesia in mice wuth induced adenomyosis”
Mol med rep – 2017
Nie J. | Liu X.

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3. I benefici del metilfolato di calcio

“Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis- associated infertility”
Eur j obstet giynecol reprod biol – 2011
Szczepańska M1. | Mostowska A. | Wirstlein P. | Lianeri M. | Marianowski P. | Skrzypczak J. | Jagodziński PP.

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“Effect of folic acid in preventing aberrant methylation of fetal endometriosisssusceptibility gene HOXA10.”
Nan Fang Yi Ke Da Xue Xue Bao. 2013
Liu M | Huang X | Xu S Li L

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4. I benefici della Curcuma

“Stimulation of macrophage migration inibitory factor expression in a endometrial stromal cells by interleukin 1, beta involving the nuclear transcription factor NFkappaB”
BIOL REPROD – 2005
Cao WG. | Morin M. | Metz C. | Maheux R. | Akoum A.

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“Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells”
FERTIL STERIL. 2009
Veillat V. | Lavoie CH. | Metz CN. | Roger T. | Labelle Y. | Akoum A.

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“Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity”
INDIAN J BIOCHEM BIOPHYS – 2009
Swarnakar S. | Paul S.

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“Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis”
INDIAN J BIOCHEM BIOPHYS – 2009
Zhang Y. | Cao H. | Hu YY. | Wang H. | Zhang CJ.

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“Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells”
PHYTOTHER RES – 2012
Kim KH. | Lee EN. | Park JK. | Lee JR. | Kim JH. | Choi HJ. | Kim BS. | Lee HW. | Lee KS. | Yoon S.

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“Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway”
BIOCHEM PHARMACOL – 2012
Jana S. | Paul S. | Swarnakar S.

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“Curcumin delays endometriosis development by inhibiting MMP-2 activity”
INDIAN J BIOCHEM BIOPHYS – 2012
Jana S. | Rudra DS. | Paul S. | Snehasikta S.

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“Curcumin inhibits endometriosis endometrial cells by reducing estradiol production”
IRAN J REPROD MED – 2013
Zhang Y. | Cao H. | Yu Z1. | Peng HY. | Zhang CJ1.

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“In vivo effects of curcumin and deferoxamine in experimental endometriosis”
ADV CLIN EXP MED. – 2017
Kizilay G. | Uz YH. | Seren G. | Ulucam E. | Yilmaz A. | Cukur Z. | Kayisli UA.

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“Inhibitory effect of curcumin in human endometriosis endometrial cells via downregulation of vascular endothelial growth factor”
MOL MED REP – 2017
Cao H. | Wei YX. | Zhou Q. | hang Y. | Guo XP. | Zhang J.

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“Upregulation of CFTR in patients with endometriosis and its involvement in NFkB-uPAR dependent cell migration”
ONCOTARGET – 2017
Huang W. | Jin A. | Zhang J. | Wang C. | Tsang LL. | Cai Z. | Zhou X. | Chen H. | Chan HC

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“Curcumin and endometriosis: Review on potential roles and molecular mechanisms”
BIOMED PHARMACOTHER – 2018
Arablou T. | Kolahdouz-Mohammadi R.

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“Systematic identification of the druggable interactions between human protein kinases and naturally occurring compounds in endometriosis”
BIOMED PHARMACOTHER – 2018
Jiang L. | Tang C. | Rao J. | Xue Q. | Wu H. | Wu D. | Zhang A. | Chen L. | Shen Z. | Lei L.

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5. I benefici dell’omega 3 e omega 6

“The effect of dietary supplementation with fish oil fatty acids on surgically induced endometriosis in the rabbit”
FERTIL STERIL. 1988
Covens AL. | Christopher P. | Casper RF

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“Effect of dietary supplementation with eicosapentaenoic acid on surgically induced endometriosis in the rabbit”
NIHON SANKA FUJINKA GAKKAI ZASSHI – 1992
Yano Y.

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“Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights”
FERTIL STERIL – 1998
Mathias JR. | Franklin R. | Quast DC. | Fraga N. | Loftin CA. | Yates L. | Harrison V.

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“High omega-3:omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis”
FERTIL STERIL – 2001
Gazvani MR. | Smith L. | Haggarty P. | Fowler PA. | Templeton A.

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“Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis”
FERTIL STERIL – 2008
Netsu S . | Konno R . | Odagiri K . | Soma M . | Fujiwara H . | Suzuki M.

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“A prospective study of dietary fat consumption and endometriosis risk”
HUM REPROD – 2010
Missmer SA. | Chavarro JE. | Malspeis S, Bertone-Johnson ER. | Hornstein MD
Spiegelman D. | Barbieri RL. | Willett WC. | Hankinson SE.

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“Elevated serum α-linolenic acid levels are associated with decreased chance of pregnancy after in vitro fertilization”
FERTIL STERIL – 2011
Jungheim ES. | Macones GA. | Odem RR. | Patterson BW. | Moley KH..

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“Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids”
IRAN BIOMED J. – 2012
Khanaki K. | Nouri M. | Ardekani AM. | Ghassemzadeh A. | Shahnazi V. | Sadeghi MR. | Darabi M. | Mehdizadeh A. | Dolatkhah H. | Saremi A. | Imani AR7, Rahimipour A

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“Effect of polyunsaturated fatty acids on secretory phospholipase A2 type IIa in ectopic endometrial cells”
IRAN J REPROD MED – 2012
Khanaki K. | Motavalizadeh Ardekani A. | Ghassemzadeh A. | Shahnazi V. | Sadeghi MR2 Darabi M. | Mehdizadeh A. | Saremi A. | Soleimani-Rad J. | Imani AR. | Nouri M. | Rahimipour A

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“Diet and endometriosis risk: a literature review”
REPROD BIOMED ONLINE – 2013
Parazzini F. | Viganò P. | Candiani M. | Fedele L.

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“Endometriosis, dysmenorrhoea and diet”
OEUR J OBSTET GYNECOL REPROD BIOL – 2013
Hansen S. | Knudsen UB./p>

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“Relationship between serum polyunsaturated fatty acids and pregnancy in women undergoing in vitro fertilization”
J CLIN ENDOCRINOL METAB – 2013
Jungheim ES. | Frolova AI. | Jiang H. | Riley JK.

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“Antioxidants for female subfertility”
COCHRANE DATABASE SYST REV – 2013
Showell MG. | Brown J. | Clarke J. | Hart RJ.

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“Differences in omega-3 and fatty acid profiles between patients with endometriosis and those with a functional ovarian cyst”
J OBSTET GYNAECOL – 2013
Kim TH. | Jo S. | Park Y. | Lee HH. | Chung SH. | Lee WS.

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“Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models”
PLOS ONE – 2013
Tomio K1. | Kawana K. | Taguchi A. | Isobe Y. | Iwamoto R. | Yamashita A. |
Kojima S. | Mori M. | Nagamatsu T. | Arimoto T. | Oda K, Osuga Y. | Taketani Y. | Kang JX. | Arai H, Arita M. | Kozuma S. | Fujii T.

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“The anti-inflammatory impact of omega-3 polyunsaturated Fattyacids during the establishment of endometriosis-like lesions”
AM J REPROD IMMUNOL – 2014
Attaman JA. | Stanic AK. | Kim M. | Lynch MP. | Rueda BR. | Styer AK.

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“Resolvins RvD1 and 17(R)-RvD1 alleviate signs of inflammation in a rat model of endometriosis”
FERTIL STERIL – 2014
Dmitrieva N. | Suess G. | Shirley R2

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“Serum Polyunsaturated Fatty Acids and Endometriosis”
REPROD SCI – 2015
Hopeman MM. | Riley JK. | Frolova AI. | Jiang H. | Jungheim ES

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“High ω-3:ω-6 fatty acids ratio increases fatty acid binding protein 4 and extracellular secretory phospholipase A2IIa in human ectopic endometrial cells”
IRAN J REPROD MED – 2014
Khanaki K. – Sadeghi MR. – Akhondi MM. – Darabi M. – Mehdizadeh A. Shabani M. – Rahimipour A. – Nouri M.

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“Nutritional aspects related to endometriosis”
REV ASSOC MED BRAS – 1992
Halpern G. | Schor E. | Kopelman A2

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“Efficacies of vitamin D and omega-3 polyunsaturated fatty acidson experimental endometriosis”
REV ASSOC MED BRAS – 1992
Akyol A. | Şimşek M. | İlhan R. | Can B. | Baspinar M. | Akyol H. |
Gül HF. | Gürsu F. | Kavak B. | Akın M

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“Influence of diet on the risk of developing endometriosis”
GINEKOL POL – 2017
Jurkiewicz-Przondziono J. | Lemm M. | Kwiatkowska-Pamuła A. | Ziółko E. | Wójtowicz MK.

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“Novel dietary supplement association reduces symptoms in endometriosis patients”
J CELL PHYSIOL – 2018
Signorile PG. | Viceconte R. | Baldi A.

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“Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages”
REPROD BIOL ENDOCRINOL -2018
Li J. | Guan L. | Zhang H. | Gao Y. | Sun J. | Gong X. | Li D. |
Chen P. | Liang X. | Huang M. | Bi H

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“A pilot randomised double blind controlled trial of the efficacy of purified fatty acids for the treatment of women with endometriosis-associated pain (PurFECT): study protocol”
PILOT FEASIBILITY STUD – 2018
Abokhrais IM. | Saunders PTK. | Denison FC. | Doust A. | Williams L. | Horne AW.

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