The Scientific Studies

endoplus

The scientific studies

Endoplus is the result of research carried out during the last 20 years by the scientific team of the Italian Endometriosis Foundation. Thanks to the medical experience and the direct relationship with patients, the Foundation is today one of the most competent and involved in scientific research on endometriosis.

Endoplus is recognized as one of the best aids to fight inflammatory symptoms, that is the determining cause of endometriosis.

Consult the studies published on international scientific heads:

 Journal of Cellular Physiology

“Novel dietary supplemente association reduces symptoms in endometriosi patiens”
Pieto G. Signorile | Rosa Viceconte | Alfonso Baldi

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6 components selected by scientific research, everyone for its specific property.

Consider the scientific insights on all Endoplus Nutrients:

1. The benefits of Partenium

“Novel dietary supplemente association reduces symptoms in endometriosi patiens”
Pietro G. Signorile | Rosa Viceconte | Alfonso Baldi

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2. The benefits of Quercetin

“Treatment approaches for painful bladder syndrome/interstitial cystis”
Drugs – 2007
Theoharides TC

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“Inhibition effect and mechanism of quercetin on surgically induced endometriosis”
Sichuan da xue xue bao yi xue ban -2009 mar
Zhang X. | Wang X. | Wng HJ. | Jang Q. | Qie MR.

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“Preliminary study of Quercetin affecting the hypotalamic-pituitary-godanal axis on rat endometriosis model”
Evid based complement alternat med – 2014
Cao Y. | Zhuang MF. | Yang Y. | Xie SW. | Cui JG. | Cao L. | Zhu Y.

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“Quercetin alleviates generalized hyperalgesia in mice wuth induced adenomyosis”
Mol med rep – 2017
Nie J. | Liu X.

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3. The benefits of Calcium Methylphate

“Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis- associated infertility”
Eur j obstet giynecol reprod biol – 2011
Szczepańska M1. | Mostowska A. | Wirstlein P. | Lianeri M. | Marianowski P. | Skrzypczak J. | Jagodziński PP.

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“Effect of folic acid in preventing aberrant methylation of fetal endometriosisssusceptibility gene HOXA10.”
Nan Fang Yi Ke Da Xue Xue Bao. 2013
Liu M | Huang X | Xu S Li L

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4. The benefits of Turmeric

“Stimulation of macrophage migration inibitory factor expression in a endometrial stromal cells by interleukin 1, beta involving the nuclear transcription factor NFkappaB”
BIOL REPROD – 2005
Cao WG. | Morin M. | Metz C. | Maheux R. | Akoum A.

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“Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells”
FERTIL STERIL. 2009
Veillat V. | Lavoie CH. | Metz CN. | Roger T. | Labelle Y. | Akoum A.

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“Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity”
INDIAN J BIOCHEM BIOPHYS – 2009
Swarnakar S. | Paul S.

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“Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis”
INDIAN J BIOCHEM BIOPHYS – 2009
Zhang Y. | Cao H. | Hu YY. | Wang H. | Zhang CJ.

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“Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells”
PHYTOTHER RES – 2012
Kim KH. | Lee EN. | Park JK. | Lee JR. | Kim JH. | Choi HJ. | Kim BS. | Lee HW. | Lee KS. | Yoon S.

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“Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway”
BIOCHEM PHARMACOL – 2012
Jana S. | Paul S. | Swarnakar S.

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“Curcumin delays endometriosis development by inhibiting MMP-2 activity”
INDIAN J BIOCHEM BIOPHYS – 2012
Jana S. | Rudra DS. | Paul S. | Snehasikta S.

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“Curcumin inhibits endometriosis endometrial cells by reducing estradiol production”
IRAN J REPROD MED – 2013
Zhang Y. | Cao H. | Yu Z1. | Peng HY. | Zhang CJ1.

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“In vivo effects of curcumin and deferoxamine in experimental endometriosis”
ADV CLIN EXP MED. – 2017
Kizilay G. | Uz YH. | Seren G. | Ulucam E. | Yilmaz A. | Cukur Z. | Kayisli UA.

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“Inhibitory effect of curcumin in human endometriosis endometrial cells via downregulation of vascular endothelial growth factor”
MOL MED REP – 2017
Cao H. | Wei YX. | Zhou Q. | hang Y. | Guo XP. | Zhang J.

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“Upregulation of CFTR in patients with endometriosis and its involvement in NFkB-uPAR dependent cell migration”
ONCOTARGET – 2017
Huang W. | Jin A. | Zhang J. | Wang C. | Tsang LL. | Cai Z. | Zhou X. | Chen H. | Chan HC

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“Curcumin and endometriosis: Review on potential roles and molecular mechanisms”
BIOMED PHARMACOTHER – 2018
Arablou T. | Kolahdouz-Mohammadi R.

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“Systematic identification of the druggable interactions between human protein kinases and naturally occurring compounds in endometriosis”
BIOMED PHARMACOTHER – 2018
Jiang L. | Tang C. | Rao J. | Xue Q. | Wu H. | Wu D. | Zhang A. | Chen L. | Shen Z. | Lei L.

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5. The benefits of Omega 3 and omega 6

“The effect of dietary supplementation with fish oil fatty acids on surgically induced endometriosis in the rabbit”
FERTIL STERIL. 1988
Covens AL. | Christopher P. | Casper RF

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“Effect of dietary supplementation with eicosapentaenoic acid on surgically induced endometriosis in the rabbit”
NIHON SANKA FUJINKA GAKKAI ZASSHI – 1992
Yano Y.

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“Relation of endometriosis and neuromuscular disease of the gastrointestinal tract: new insights”
FERTIL STERIL – 1998
Mathias JR. | Franklin R. | Quast DC. | Fraga N. | Loftin CA. | Yates L. | Harrison V.

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“High omega-3:omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis”
FERTIL STERIL – 2001
Gazvani MR. | Smith L. | Haggarty P. | Fowler PA. | Templeton A.

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“Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis”
FERTIL STERIL – 2008
Netsu S . | Konno R . | Odagiri K . | Soma M . | Fujiwara H . | Suzuki M.

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“A prospective study of dietary fat consumption and endometriosis risk”
HUM REPROD – 2010
Missmer SA. | Chavarro JE. | Malspeis S, Bertone-Johnson ER. | Hornstein MD
Spiegelman D. | Barbieri RL. | Willett WC. | Hankinson SE.

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“Elevated serum α-linolenic acid levels are associated with decreased chance of pregnancy after in vitro fertilization”
FERTIL STERIL – 2011
Jungheim ES. | Macones GA. | Odem RR. | Patterson BW. | Moley KH..

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“Evaluation of the relationship between endometriosis and omega-3 and omega-6 polyunsaturated fatty acids”
IRAN BIOMED J. – 2012
Khanaki K. | Nouri M. | Ardekani AM. | Ghassemzadeh A. | Shahnazi V. | Sadeghi MR. | Darabi M. | Mehdizadeh A. | Dolatkhah H. | Saremi A. | Imani AR7, Rahimipour A

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“Effect of polyunsaturated fatty acids on secretory phospholipase A2 type IIa in ectopic endometrial cells”
IRAN J REPROD MED – 2012
Khanaki K. | Motavalizadeh Ardekani A. | Ghassemzadeh A. | Shahnazi V. | Sadeghi MR2 Darabi M. | Mehdizadeh A. | Saremi A. | Soleimani-Rad J. | Imani AR. | Nouri M. | Rahimipour A

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“Diet and endometriosis risk: a literature review”
REPROD BIOMED ONLINE – 2013
Parazzini F. | Viganò P. | Candiani M. | Fedele L.

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“Endometriosis, dysmenorrhoea and diet”
OEUR J OBSTET GYNECOL REPROD BIOL – 2013
Hansen S. | Knudsen UB./p>

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“Relationship between serum polyunsaturated fatty acids and pregnancy in women undergoing in vitro fertilization”
J CLIN ENDOCRINOL METAB – 2013
Jungheim ES. | Frolova AI. | Jiang H. | Riley JK.

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“Antioxidants for female subfertility”
COCHRANE DATABASE SYST REV – 2013
Showell MG. | Brown J. | Clarke J. | Hart RJ.

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“Differences in omega-3 and fatty acid profiles between patients with endometriosis and those with a functional ovarian cyst”
J OBSTET GYNAECOL – 2013
Kim TH. | Jo S. | Park Y. | Lee HH. | Chung SH. | Lee WS.

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“Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models”
PLOS ONE – 2013
Tomio K1. | Kawana K. | Taguchi A. | Isobe Y. | Iwamoto R. | Yamashita A. |
Kojima S. | Mori M. | Nagamatsu T. | Arimoto T. | Oda K, Osuga Y. | Taketani Y. | Kang JX. | Arai H, Arita M. | Kozuma S. | Fujii T.

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“The anti-inflammatory impact of omega-3 polyunsaturated Fattyacids during the establishment of endometriosis-like lesions”
AM J REPROD IMMUNOL – 2014
Attaman JA. | Stanic AK. | Kim M. | Lynch MP. | Rueda BR. | Styer AK.

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“Resolvins RvD1 and 17(R)-RvD1 alleviate signs of inflammation in a rat model of endometriosis”
FERTIL STERIL – 2014
Dmitrieva N. | Suess G. | Shirley R2

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“Serum Polyunsaturated Fatty Acids and Endometriosis”
REPROD SCI – 2015
Hopeman MM. | Riley JK. | Frolova AI. | Jiang H. | Jungheim ES

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“High ω-3:ω-6 fatty acids ratio increases fatty acid binding protein 4 and extracellular secretory phospholipase A2IIa in human ectopic endometrial cells”
IRAN J REPROD MED – 2014
Khanaki K. – Sadeghi MR. – Akhondi MM. – Darabi M. – Mehdizadeh A. Shabani M. – Rahimipour A. – Nouri M.

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“Nutritional aspects related to endometriosis”
REV ASSOC MED BRAS – 1992
Halpern G. | Schor E. | Kopelman A2

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“Efficacies of vitamin D and omega-3 polyunsaturated fatty acidson experimental endometriosis”
REV ASSOC MED BRAS – 1992
Akyol A. | Şimşek M. | İlhan R. | Can B. | Baspinar M. | Akyol H. |
Gül HF. | Gürsu F. | Kavak B. | Akın M

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“Influence of diet on the risk of developing endometriosis”
GINEKOL POL – 2017
Jurkiewicz-Przondziono J. | Lemm M. | Kwiatkowska-Pamuła A. | Ziółko E. | Wójtowicz MK.

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“Novel dietary supplement association reduces symptoms in endometriosis patients”
J CELL PHYSIOL – 2018
Signorile PG. | Viceconte R. | Baldi A.

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“Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages”
REPROD BIOL ENDOCRINOL -2018
Li J. | Guan L. | Zhang H. | Gao Y. | Sun J. | Gong X. | Li D. |
Chen P. | Liang X. | Huang M. | Bi H

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“A pilot randomised double blind controlled trial of the efficacy of purified fatty acids for the treatment of women with endometriosis-associated pain (PurFECT): study protocol”
PILOT FEASIBILITY STUD – 2018
Abokhrais IM. | Saunders PTK. | Denison FC. | Doust A. | Williams L. | Horne AW.

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